Our projects
Research Unit for Rare Diseases, First Faculty of Medicine at Charles University in Prague, General University Hospital and BIOCEV
NW26-07-00090 Identification and characterization of genetics facotrs of hereditary tubulointerstitial kidney disease III; Grant provider: Grant provider: Ministry of Health of the Czech Republic; Main recipient: Charles University – First Faculty of Medicine; Project lead: Mgr. Martina Živná, Ph.D.; Period of research project: 2026-2029
26-21355S Heterodimerization of human GLP-G9a histone methyltransferase and abnormal epigenetics in Kleefstra syndrome; Grant provider: The Czech Science Foundation (GACR); Main recipient: Charles University – First Faculty of Medicine; Project lead: Ing. Aleš Hnízda Ph.D.; Period of research project: 2026-2029
26-21263S Enhancing PRPF31 expression as a therapeutic strategy for retinitis pigmentosa 11; Grant provider: The Czech Science Foundation (GACR); Main recipient: Charles University – First Faculty of Medicine; Project lead: prof. David Staněk, Ph.D.; Period of research project: 2026-2029
CZ.02.01.01/00/23_020/0008540 - Multi-omics platform for the search for biological correlates of diseases and the development of new diagnostic, preventive and therapeutic procedures (MULTIOMICS.CZ); Grant provider: The Ministry of Education, Youth and Sports (MEYS, MŠMT), Main recipient: Charles University - First Faculty of Medicine; Project lead: prof. Ing. Stanislav Kmoch CSc.; Period of research project: 2025 – 2028
LUAUS25093 - Genetic causes and therapy of rare hereditary amyloidoses, Grant provider: The Ministry of Education, Youth and Sports (MEYS, MŠMT), Main recipient: Charles University - First Faculty of Medicine; Project lead: MUDr. Jakub Sikora, Ph.D; Period of research project: 2025 – 2028
LUAUS24087 - Identification and characterization of genetic causes of hereditary tubulointerstitial kidney diseases, Grant provider: The Ministry of Education, Youth and Sports (MEYS, MŠMT), Main recipient: Charles University - First Faculty of Medicine; Project lead: prof. Ing. Stanislav Kmoch CSc.; Period of research project: 2024 – 2028
NW24-04-00067 Hereditary movement disorders: genetic variability of parkinsonian and hyperkinetic syndromes, Grant provider: MZ0 – Ministry of Health of the Czech Republic; Main recipient: General University Hospital in Prague (VFN) and Charles University - First Faculty of Medicine; Project leaders: Doc. MUDr. Jiří Klempíř, Ph.D and MUDr. Jakub Sikora, Ph.D; Period of research project: 2024 – 2027
UNCE - 24/MED/022 - Center for the Study of Rare Genetic Disorders II, Grant provider: Charles University (university grant UNCE – University research centers), Main recipient: First Faculty of Medicine; Project lead: prof. Ing. Stanislav Kmoch CSc.; Period of research project: 2024-2029
NW25-07-00303 - Optimization of corneal endothelial failure diagnostics in clinical practice and transplantology; Grant provider: Ministry of Health of the Czech Republic; Main recipient: Charles University - First Faculty of Medicine; Project lead: Ing. Ľubica Ďuďáková, PhD; Period of research project: 2025 – 2028
NU23-08-00123 - Improving diagnostics and treatment in patients with ultra-rare diseases using advanced forms of genomic analysis and artificial intelligence, in connection with new methods of digitizing their phenotype; Grant provider: AZV - Agency for Health Research of the Czech Republic; Main recipient: Charles University - First Faculty of Medicine; Project lead: prof. MUDr. Petra Lišková, MD, Ph.D; Period of research project: 2025 – 2028, Note: Only the project proposal was found.
GA24-10324S - Exploring the Molecular Basis of Anterior Segment Dysgenesis using Advanced Sequencing and Organoid Technology; Grant provider: Czech Science Foundation; Main recipient: Charles University - First Faculty of Medicine; Project lead: prof. MUDr. Petra Lišková, MD, Ph.D; Period of research project: 2024 - 2026
NW24-03-00092 - Variants of uncertain significance in the CHEK2 gene: their functional classification and characterization of tumors in carriers of pathogenic mutations II, Grant provider: MZ0 – Ministry of Health of the Czech Republic; Main recipient: Institute of Molecular Genetics of the Czech Academy of Sciences, General University Hospital in Prague (VFN) and Charles University - First Faculty of Medicine; Project leaders: MUDr. Libor Macůrek, PhD., MUDr. Petra Kleiblová, prof. MUDr. Zdeněk Kleibl, PhD., Period of research project: 2024 – 2027
RVO-VFN 64165 (subproject GIP-23-L-09-846) – Idenitification of Genetic Oncologic Risks (IGOR); Grant provider: Ministry of Health of the Czech Republic; Main recipient: General Faculty Hospital in Prague Charles University - First Faculty of Medicine; Institutional Support – Project for the Long-Term Strategic Development of a Research Organization; Project lead: prof. MUDr. Zdeněk Kleibl, PhD.
SVV260631 - Methodology of Biomedical Research (Student Scientific Project); Grant provider: Charles University; Main recipient: First Faculty of Medicine; Project lead: prof. Ing. Stanislav Kmoch CSc.;
Collaboration between the First Faculty of Medicine, Charles University, and the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences on the project for the development of a repository for sharing genomic and medical data within the European FEGA platform. (18.12.2024)
NU23-07-00281 Characterization of the molecular basis of rare genetic diseases of pediatric onset using new methods of genome analysis II. Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Charles University / 1st Medicine faculty; Recipient: prof. Ing. Stanislav Kmoch, CSc.; Period of research project: 2023 - 2026
LM2023067 The National Center for Medical Genomic, Grant provider: The Ministry of Education, Youth and Sports (MEYS, MŠMT), Main recipient: Charles University in Prague / First Faculty of Medicine, Recipient: prof. Ing. Stanislav Kmoch, CSc. Period of research project: 2023 - 2026
TN02000132 National centre for new methods of diagnosis, monitoring, treatment and prevention of genetic diseases, Grant provider: Technology Agency of the Czech Republic Main recipient: Institute of Molecular Genetics of the Czech Academy of Sciences, Recipient: PD. Dr. rer. nat. ha Radislav Sedláček, Period of research project: 2023 - 2026
NU23-01-00500 Identification and characterization of genetic factors and pathogenetic mechanism of defects affecting de novo purine metabolism, Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Charles University / 1st Medicine faculty; Recipient: Ing. Marie Zikánová, PhD.; Period of research project: 2023 – 2026
NU23-03-00150 Classification of variants of unknown significance in cancer susceptibility genes by the multiplex PCR/NGS-based analysis of their impact on pre-mRNA splicing (II)), Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: General University Hospital in Prague (VFN) ; Recipient : MUDr. Petra Kleiblová, Ph.D., Period of research project: 2023 – 2026
GA25-16979S - Spatially resolved single-cell transcriptomic map of human ischemic brain; Grant provider: Czech Science Foundation; Main recipient: Institute of Biotechnology of the Czech Academy of Sciences; Project lead: Ing. Lukáš Valihrach Ph.D.; Period of research project: 2025 – 2027
GA24-11364S - A humanized organoid-based platform for stroke modelling and mRNA-based therapeutic intervention; Grant provider: Czech Science Foundation; Main recipient: Institute of Biotechnology of the Czech Academy of Sciences; Project lead: Ing. Lukáš Valihrach Ph.D.; Period of research project: 2024 – 2026
10112569 - Activation and switch of fates in T lymphocytes; Grant provider: Horizon Europe; Main recipient: Institute of Molecular Genetics of the Czech Academy of Sciences; Project lead: Mgr. Ondřej Štěpánek, Ph.D.; Period of research: 2025 - 2029
Strategie AV21 – Fungi - new threats and opportunities; Grant provider: Czech Academy of Sciences; Coordinating Centre: Institute of Microbiology of the Czech Academy of Sciences; Project coordinator: Mgr. Miroslav Kolařík, Ph.D.; Period of research project: 2024 - 2028
Solved projects
NU22-03-00276 - Functional classification of the TP53 gene variants with distinct penetrance and its use for better management of cancer prevention in mutation carriers, Grant provider: MZ0 – Ministry of Health of the Czech Republic; Main recipient: Institute of Molecular Genetics of the Czech Academy of Sciences, General University Hospital in Prague (VFN), Project leaders: MUDr. Libor Macůrek, PhD., MUDr. Petra Kleiblová; Period of research project: 2022-2025
LX22NPO5107 National Institute for Neurological Research, Grant provider: The Ministry of Education, Youth and Sports (MEYS, MŠMT), Main recipient: St. Anne's University Hospital in Brno, Recipient: prof. MUDr. Milan Brázdil, Ph.D., Period of research project: 2022-2025
LX22NPO5104 National Institute for Research of Metabolic and Cardiovascular Diseases, Grant provider: The Ministry of Education, Youth and Sports (MEYS, MŠMT), Main recipient: Institute for Clinical and Experimental Medicine, Recipient: : prof. MUDr. Martin Haluzík, DrSc., Period of research project: 2022 – 2025
LX22NPO5102 National institute for cancer research, Grant provider: The Ministry of Education, Youth and Sports (MEYS, MŠMT), Main recipient: Charles University in Prague / First Faculty of Medicine, Recipient: prof. MUDr. Aleksi Šedo, Period of research project: 2022 – 2025
NU22-07-00474 Molecular genetic causes and biochemical consequences of Congenital disorders of glycosylation, Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Charles University / 1st Medicine faculty; Recipient: RNDr. Hana Hansíková, CSc., Period of research project: 2022 – 2025
GA23-05327S - Astrocyte-microglia communication as a target for stroke therapy; Grant provider: Czech Science Foundation; Main recipient: Institute of Biotechnology of the Czech Academy of Sciences; Project lead: Ing. Lukáš Valihrach Ph.D.; Period of research project: 2023 – 2025
NU22-03-00182 - Circulating Tumor DNA and its Prognostic Impact in Hodgkin Lymphoma; Grant provider: Ministry of Health of the Czech Republic; Main recipient: Faculty Hospital Královské Vinohrady; Other recipient: Charles University - First Faculty of Medicine; Project leads: MUDr. Heidi Móciková Ph.D., MUDr. Ondřej Havránek Ph.D.; Období řešení projektu: 2022 – 2025
NU21-03-00411 - Early identification of prognostic factors connected with worse outcome of Non-Hodgkin’s Lymphoma; Grant provider: Ministry of Health of the Czech Republic; Main recipient: General Faculty Hospital in Prague; Other recipient: Charles University - First Faculty of Medicine; Project lead: prof. MUDr. Marek Trněný CSc.; Period of research project: 2021 – 2025
NU22-03-00210 - Genomic characterization of adult B-precursor acute lymphoblastic leukemia for prediction of treatment response to targeted therapy; Grant provider: Ministry of Health of the Czech Republic; Main recipient: Institute of Hematology and Blood Transfusion; Project lead: doc. MUDr. Cyril Šálek Ph.D.; Period of reasearch project: 2022 – 2025
NU22-07-00614 Mitochondrial optic neuropathies: a complex genetic and metabolomic analysis to characterize molecular bases and to identify novel biomarkers, Grant provider: Ministry Of Health Of The Czech Republic, Main recipient: Charles University / 1st Medicine faculty; Recipient: prof. MUDr. Petra Lišková, MD, Ph.D., Period of research project: 2022 – 2025
NU21-07-00033 Identification and characterization of genetic factors contributing to inherited tubulointerstitial kidney disease II. Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Charles University / 1st Medicine faculty; Recipient: Mgr. Martina Živná, Ph.D. Period of research project: 2021-2024
NU21-08-00324 Evaluation of new biomarkers of Fabry disease in selected groups of patients in the Czech Republic, Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Charles University / 1st Medicine faculty; Recipient: RNDr. Ladislav Kuchař, Ph.D. Period of research project: 2021 – 2024
NU21-07-00225 - Spectrum of NGS detected somatic mutations and their association with prognosis and outcome of adolescent and young adult patients with Ph-positive leukemia; Grant provider: Ministry of Health of the Czech Republic; Main recipient: Institute of Hematology and Blood Transfusion; Project lead: doc. Mgr. Kateřina Machová Poláková Ph.D.; Period of research project: 2021 – 2024
NU22-A-123 Prognostic factors affecting treatment outcomes and mortality in COVID-19 patients, new diagnostic methods, current and new terapeutic opportunities for COVID-19, Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Thomayer University Hospital, Recipient: Doc. MUDr. Roman Zazula, Ph.D., Period of research project: 2022 – 2023
NU20-03-00285 BIOINFORMATICS AND FUNCTIONAL ANALYSES OF SUSCEPTIBILITY VARIANTS SUPPORTING THE NGS-BASED TESTING OF HEREDITARY CANCERS IN THE CZECH REPUBLIC (II), Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Charles University / 1st Medicine faculty; Recipient: Prof. MUDr. Zdeněk Kleibl, Ph.D Period of research project: 2020 – 2023
NU20-07-00026 Changes of transcriptome during early postnatal development in humans: impact of premature birth on control of energy metabolism, Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Institute of Physiology of the Czech Academy of Sciences, Recipient: : MUDr. Jan Kopecký, DrSc., Period of research project: 2020-2023
NU20-03-00283 Hereditary cancer predisposition in breast or colorectal cancer patients not indicated for routine genetic testing, Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Charles University / 1st Medicine faculty; Recipient: MUDr. Petra Kleiblová, Ph.D. Period of research project: 2020 – 2023
GA20-19278S Corneal endothelial dystrophies - genetic causes and molecular mechanisms, Grant provider: The Czech Science Foundation; Main recipient: Charles University / 1st Medicine faculty; Recipient: prof. MUDr. Petra Lišková, MD, Ph.D., Period of research project: 2020 – 2023
NU20-07-00182 Childhood-onset retinal dystrophies; multidisciplinary management with novel approaches to accelerate molecular diagnosis and to explore disease mechanisms, Grant provider: Ministry Of Health Of The Czech Republic, Main recipient: Charles University / 1st Medicine faculty; Recipient: prof. MUDr. Petra Lišková, MD, Ph.D., Period of research project: 2020 – 2023
NV19-08-00122 Improved Interpretation of Next Generation Sequencing Datasets in Patients with Inherited Cardiomyopathy Using Functional Models Based on Induced Pluripotent Stem Cells and Advanced Cardiac Imaging in Families, Grant provider: Ministry Of Health Of The Czech Republic, Main recipient: Charles University / 1st Medicine faculty; Recipient: RNDr. Robert Dobrovolný, Ph.D., Period of research project: 2019 – 2023
NV19-08-00137 The application of new methods of genomic analysis in cases of rare genetic based diseases with negative results of genetic and genomic analyses. Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Charles University / 1st Medicine faculty; Recipient: Mgr. Viktor Stránecký, PhD; Period of research project: 2019 - 2023
NU20-04-00332 Organic and functional comorbidities in functional movement disorders, common pathophysiological mechanisms, biomarkers and prognostic factors, Grant provider: Ministry Of Health Of The Czech Republic, Main recipient: Charles University / 1st Medicine faculty; Recipient: MUDr. Tereza Serranová, Ph.D., Period of research project: 2020 – 2023
LM2018132 The National Center for Medical Genomic, Grant provider: The Ministry of Education, Youth and Sports (MEYS, MŠMT), Main recipient: Charles University in Prague / First Faculty of Medicine, Recipient: Prof. Ing. Stanislav Kmoch, CSc. Period of research project: 2020 - 2022
8F20004 Solving missing heritability in inherited retinal diseases using integrated omics and gene editing in human cellular and animal models, Grant provider: The Ministry of Education, Youth and Sports (MEYS, MŠMT), Main recipient: Charles University / 1st Medicine faculty; Recipient: doc. MUDr. Petra Lišková, Ph.D., Period of research project: 2020 – 2022
EF18_046/0015515 Modernization and instrumental upgrade of the National Center for Medical Genomics, Grant provider: The Ministry of Education, Youth and Sports (MEYS, MŠMT), Main recipient: Charles University in Prague / First Faculty of Medicine, Recipient: Prof. Ing. Stanislav Kmoch, CSc. Period of research project: 2020 - 2021
LTAUSA19068 Advancing the diagnosis, understanding, and treatment of inherited kidney disease related to mucin-1 through improved family identification and new genetic, molecular, and biochemical approaches, Grant provider: The Ministry of Education, Youth and Sports (MEYS, MŠMT), Main recipient: Charles University in Prague / First Faculty of Medicine, Recipient: prof. Ing. Stanislav Kmoch, CSc. Period of research project: 2019 - 2022
8F19002 Towards a new era for the identification and characterisation of inborn errors of glycosylation, Grant provider: The Ministry of Education, Youth and Sports (MEYS, MŠMT), Main recipient: Charles University / 1st Medicine faculty; Recipient: RNDr. Hana Hansíková, CSc., Period of research project: 2019 – 2022
NV19-07-00136 Characterization of the molecular basis of rare genetic diseases of pediatric onset using new methods of genome analysis. Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Charles University / 1st Medicine faculty; Recipient: Prof. Ing. Stanislav Kmoch, CSc.; Period of research project: 2019 - 2022
779257 Solving the unsolved Rare Diseases — Solve-RD, Grant provider: Horizon 2020, H2020-SC1-2017-Single-Stage-RTD, Period of research project: 2018 – 2022
NV18-06-00032 Molecular basis and mechanisms of familial intrahepatic cholestasis, Grant provider: Ministry Of Health Of The Czech Republic, Main recipient: Institute for Clinical and Experimental Medicine; Recipient: : Prof. MUDr. Mgr. Milan Jirsa, CSc., Period of research project: 2018 – 2022
NV18-03-00024 Classification of variants of unknown significance in cancer susceptibility genes by the multiplex PCR/NGS-based analysis of their impact on pre-mRNA splicing, ,Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Charles University / 1st Medicine faculty; Recipient: MUDr. Petra Kleiblová, Ph.D. Period of research project: 2018 – 2021
NV17-30965A Mitochondrial disorders with instability of mitochondrial DNA, Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Charles University / 1st Medicine faculty; Recipient: Ing. Markéta Tesařová, Ph.D., Period of research project: 2017 – 2021
17-29786A Identification and characterization of genetic factors contributing to inherited tubulointerstitial kidney disease. Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Charles University / 1st Medicine faculty; Recipient: Mgr. Martina Živná, Ph.D.; Period of research project: 2017-2020
NV17-30500A Congenital cataracts - next-generation sequencing in diagnosis and management, Grant provider: Ministry Of Health Of The Czech Republic, Main recipient: Charles University / 1st Medicine faculty; Recipient: prof. MUDr. Petra Lišková, MD, Ph.D., Period of research project: 2017 – 2020
EF16_013/0001634 National Centrum of Medical Genomics - modernization of infrastructure and research of genetic variation in the population, Grant provider: The Ministry of Education, Youth and Sports (MEYS, MŠMT), Main recipient: Charles University in Prague / First Faculty of Medicine, Recipient: Prof. Ing. Stanislav Kmoch, CSc. Period of research project: 2017 - 2019
LQ1604 BIOCEV: from Fundamental to Applied Research, Grant provider: The Ministry of Education, Youth and Sports (MEYS, MŠMT), Main recipient: Institute of Molecular Genetics of the Czech Academy of Sciences, Recipient: doc. RNDr. Radislav Sedláček, Ph.D., Period of research project: 2016 – 2020
NV16-29959A Bioinformatics and functional analyses of susceptibility variants supporting the NGS-based testing of hereditary cancers in the Czech Republic, Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Charles University / 1st Medicine faculty; Recipient : : Prof. MUDr. Zdeněk Kleibl, Ph.D Period of research project: 2016 – 2019
NV15-27682A Next generation sequencing for early diagnosis and individualized treatment of dilated cardiomyopathy and related forms of cardiomyopathy, Grant provider: Ministry Of Health Of The Czech Republic, Main recipient: Institute for Clinical and Experimental Medicine; Recipient: MUDr. Miloš Kubánek, Ph.D., Period of research project: 2015 – 2019
NV15-27695A Characterization of genetic predisposition to ovarian cancer using Next Gene Sequencing analysis ,Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Charles University / 1st Medicine faculty; Recipient: MUDr. Petra Kleiblová, Ph.D. Period of research project: 2015 – 2018
NV15-28830A Identification of genetic factors contributing to hereditary breast cancer development and prognosis; Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Charles University / 1st Medicine faculty; Recipient: Prof. MUDr. Zdeněk Kleibl, Ph.D Period of research project: 2015 – 2018
15-28208A Characterization of the molecular basis of rare genetic diseases of pediatric onset using new methods of genome analysis, Grant provider: MZ0 - Ministry Of Health Of The Czech Republic. Main recipient: Charles University in Prague / First Faculty of Medicine, Period of research project: 2015-2018.
GB14-36804G Center of mitochondrial biology and pathology (MITOCENTRUM), Grant provider: GA0 - The Czech Science Foundation (GA CR), Main recipient: Institute of Physiology CAS, Period of research project: 2014-2018.
GA14-21903S Genetic architecture of impulsive violence, Grant provider: GA0 - The Czech Science Foundation (GA CR), Main recipient: Charles University in Prague / First Faculty of Medicine, Period of research project: 2014-2016.
NT14025 Role of rare variants in genetic predisposition to statin myopathy, Grant provider: MZ0 - Ministry Of Health Of The Czech Republic, Main recipient: Institute for Clinical and Experimental Medicine, Period of research project: 2013-2015.
NT13116 Identification of the genetic and molecular basis of rare genetic disorders using novel genomic methods, Grant provider: MZ0 - Ministry Of Health Of The Czech Republic, Main recipient: Charles University in Prague / First Faculty of Medicine, Period of research project: 2012-2015.
LH12015 Identification and characterization of genetic factors contributing to chronic kidney disease, Grant provider: The Ministry of Education, Youth and Sports (MEYS, MŠMT), Main recipient: Charles University in Prague / First Faculty of Medicine, Period of research project: 2012-2015.
International projects
313011ATA2 PROMEDICOV-19 Research into progressive methods for diagnosing COVID-19 and the biomarkers enabling early detection of individuals at increased risk of severe course of the disease, Grant provider: Ministry of transport and construction of the Slovak Republic, Ministry of Education, Science, Research and Sports of the Slovak Republic and the Research Agency; Project is co-financed by the EU; Recipient: MEDIREX GROUP ACADEMY n.o., Period of research project: 2020 – 2023
PP-COVID-20-0056 Creation of a system of early and rapid detection, identification and diagnosis of new infectious diseases with pandemic potential Research and Development Support Agency – pilot study COVID-19, Grant provider: Research and Development Support Agency, Recipient: MEDIREX GROUP ACADEMY n.o., Start of research project: 2020
B1MG, 951724 Beyond 1M Genomes’ B1MG. Grant provider: European Union, Horizon2020; Period of research project: 2020-2023
831390 Orphanet Network — ONW. Grant provider: Public health EU DG Sante; Period of research project: 2018-2021
Second Faculty of Medicine at Charles University, Motol University Hospital
Solved projects
NU22-07-00165 - Identification and analysis of genes and genetic defects causing rare neurodevelopmental disorders in children; Grant provider Ministry of Health of the Czech Republic; Main recipient: Charles University Univerzita Karlova / 2nd Faculty of Medicine; Main recipient: prof. Ing. Zdeněk Sedláček DrSc; Period of research project: 2022 – 2025
ZD-ZDOVA2-001 Improvement of targetted prevention and early diagnostics in specific communicable and non-communicable diseases in selected socially excluded localities with Romani communities. Grant provider: Fonds Norway Grants a EHP; Main recipient: Motol University Hospital; Period of research project: 2021-2024
NU20-07-00049 Intestinal organoids as an in-vitro model for predicting the response to therapies correcting molecular defects in cystic fibrosis. Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Charles University / 2nd Medicine faculty; Period of research project: 2020-2023
NV19-06-00189 Genetic factors of progressive hearing loss of cochlear implantation candidates: a potential for stratification of their therapy. Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Motol University Hospital; Period of research project: 2019-2022
NV19-06-00443 Genetics of adult-onset familial focal segmental glomerulosclerosis (FSGS) – implications for individualized therapy and successful kidney transplantation. Main recipient: Motol University Hospital; Period of research project: 2019-2022
NV18-02-00237 Detection of sudden cardiac death causes in people aged 0-35 years using molecular genetic methods – a pilot study. Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Charles University / 2nd Medicine faculty; Period of research project: 2018-2021
15-34904A Next generation sequencing in early Diagnosis and individualised therapy of hypertrophic cardiomyopathies, Grant provider: AZV ČR. Period of research project: 2015-2018.
LD14073 Introduction of next generation sequencing into clinical diagnostics in the Czech Republic: ethical and clinical genetic indication criteria, Grant provider: COST. Period of research project: 2014-2017.
CZ.2.16/3.1.00/24022 Improvement of early Diagnosis, prevention and therapy of severe reproductive-, prenatal and postnatal developmental disorders in children and adults: sustainability period, Grant provider: Operační program Praha Konkurenceschopnost. Period of research project: 2013-2018.
NF-CZ11-PDP-3-003-2014 National Coordinating Centre for rare diseases at the Motol University Hospital, Grant provider: Norway Grants. Period of research project: 2014-2017.
305444 RD-CONNECT, An integrated platform connecting registries, biobanks and clinical bioinformatics for rare disease research, Grant provider: FP7. Period of research project: 2012-2018.
Masaryk University – CEITEC
CZ.02.01.01/00/23_020/0008555 - Applicability of Comprehensive Genomic Testing – towards better diagnostics (ACGT2), Grant provider: The Ministry of Education, Youth and Sports (MEYS, MŠMT), Main recipient: Masaryk University in Brno; Project lead: prof. RNDr. Šárka Pospíšilová, Ph.D., Period of research project: 2025 – 2028
GA24-12028S - Constructing the Developmental Atlas of Alzheimer’s Disease using Cerebral Organoids and Single-Cell Transcriptomics; Grant provider: Czech Science Foundation; Main recipient: Masaryk university / Faculty of medicine; Other recipient: Institute of Biotechnology of the Czech Academy of Sciences; Project lead: Ing. Lukáš Valihrach Ph.D.; Period of research project: 2024 – 2026
Solved projects
NU22-03-00290 Study on exosomal microRNAs in gliomas: implications for diagnostics and innovative therapy, Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Masaryk University / CEITEC; Recipient: doc. Mgr. Jiří Šána, Ph.D., Period of research project: 2022 – 2025
GA22-35273S New approaches to Chimeric Antigen Receptor T cells: analysis of RASAL3 protein function and identification of novel CAR-T activity-modifying genes, Grant provider GA0 – Czech Science Foundation; Main recipient: Masaryk University / CEITEC; Recipient: doc. Michal Šmída, PhD., Period of research project: 2022 – 2024
NU21-04-00305 Transcriptomics and DNA methylation analysis in patients with focal cortical dysplasia, Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Masaryk University / Medicine Faculty; Recipient: MUDr. Milan Brázdil, PhD., Period of research project: 2021 – 2024
NU20-03-00240 Whole exome, low-coverage genome and transcriptome sequencing as tools for precision oncology in paediatric patients with high-risk and relapsed solid tumors, Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Masaryk University / Medicine Faculty; Recipient: prof. MUDr. Jaroslav Štěrba, Ph.D., Period of research project: 2020 – 2023
NU20-08-00137 Searching and functional testing of gene variants predisposing to familial haematopoietic disorders, Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Masaryk University / CEITEC; Recipient: Prof. MUDr. Michael Doubek, Ph.D., Period of research project: 2020 – 2023
NU20-08-00314 Single cell analysis: a modern tool to study clonal evolution in high-risk patients with chronic lymphocytic leukemia, Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Masaryk University / CEITEC; Recipient: prof. RNDr. Šárka Pospíšilová, Ph.D., Period of research project: 2020 – 2023
NV19-03-00562 Global methylation profiles and comprehensive analysis of gene fusions as a basis for therapeutic planning in pediatric oncology, Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Masaryk University / Medicine Faculty; Recipient: prof. MUDr. Jaroslav Štěrba, Ph.D., Period of research project: 2019 – 2023
NV19-03-00501 Study of PIWI-interacting RNAs in glioblastoma stem cells and their potential clinical implications, Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Masaryk University / CEITEC; Recipient: doc. Mgr. Jiří Šána, Ph.D., Period of research project: 2019 – 2023
EF16_026/0008448 Analysis of Czech Genomes for Theranostics, Grant provider: The Ministry of Education, Youth and Sports (MEYS, MŠMT) ; Main recipient: Masaryk University / CEITEC; Recipient: prof. RNDr. Šárka Pospíšilová, Ph.D., Period of research project: 2019 – 2023
GA19-20873S Driver mutations in cancer genome of Nothobranchius furzeri: from tumor biology to concept of experimental model of spontaneous carcinogenesis, Grant provider GA0 – Czech Science Foundation; Main recipient: Masaryk University / CEITEC; Recipient: prof. RNDr. Ondřej Slabý, Ph.D., Period of research project: 2019 – 2023
NV19-03-00091 Comprehensive prognostic and predictive panel for chronic lymphocytic leukemia: a next-generation sequencing tool suitable for clinical practice and study of genetic architecture behind the disease evolution, Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Masaryk University / CEITEC; Recipient: prof. RNDr. Šárka Pospíšilová, Ph.D., Period of research project: 2019 – 2022
GA19-11931S The role of miRNA in development of glutamatergic and GABAergic signaling after early-life seizures, Grant provider GA0 – Czech Science Foundation; Main recipient: Masaryk University / CEITEC; Recipient: prof. MUDr. Milan Brázdil, Ph.D., Period of research project: 2019 – 2022
TJ02000049 Development and validation of innovative detection systems for quantification of urinary microRNAs in diagnosis of urologic cancers, Grant provider TA0 Technologic agentury of the Czech Republic; Main recipient: Masaryk University / CEITEC; Recipient: Mgr. Jiří Šána, Ph.D., Period of research project: 2019 – 2021
NV18-03-00054 THE ROLE OF MICRORNAS AND THEIR TARGETS IN THE TRANSFORMATION OF FOLLICULAR LYMPHOMA AND AGGRESSIVENESS OF CHRONIC LYMPHOCYTIC LEUKEMIA, Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Masaryk University / CEITEC; Recipient: Doc. MUDr. Mgr. Marek Mráz, Ph.D., Period of research project: 2018 – 2021
GA16-18257S Uncovering the mechanism underlying the tumor-suppressive effects of miR-215 and its substitution as new therapeutic strategy in colorectal cancer, Grant provider GA0 – Czech Science Foundation; Main recipient: Masaryk University / CEITEC; Recipient: prof. RNDr. Ondřej Slabý, Ph.D., Period of research project: 2016 – 2020
GA16-04726S miRNA and biochemical pathways in epilepsy, Grant provider GA0 – Czech Science Foundation; Main recipient: Masaryk University / CEITEC; Recipient: prof. MUDr. Milan Brázdil, Ph.D.,Period of research project: 2016 – 2020
NV16-34414A Determination of genetic regions susceptible to splicing affecting mutations, Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Masaryk University / CEITEC, Recipient: prof. MUDr. Tomáš Freiberger, Ph.D., Period of research project: 2016 – 2019
NV16-33209A Genome-wide expression profiling and mutation analysis as the diagnostic basis for personalized pediatric cancer treatment plans: a feasibility study, Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Masaryk University / Medicine faculty, Recipient: prof. MUDr. Jaroslav Štěrba, Ph.D., Period of research project: 2016 – 2019
NV16-29447A Searching for mutations predisposing to familial hematologic and oncologic diseases), Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Masaryk University / CEITEC, Recipient: Prof. MUDr. Michael Doubek, Ph.D., Period of research project: 2016 – 2019
NV15-31834A Selection of genomic defects in chronic lymphocytic leukemia and their impact on disease outcome, Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Masaryk University / CEITEC, Recipient: prof. RNDr. Šárka Pospíšilová, Ph.D., Period of research project: 2015 – 2018
NV15-33561A Resistance to monoclonal antibody therapy at B-CLL and B-lymphomas: its foundations and potential intervention strategies, Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: Masaryk University / CEITEC, Recipient: Mgr. Michal Šmída, Ph.D., Period of research project: 2015 – 2018
Project NGS-PTL - Next Generation Sequencing Platform for Targeted Personalized Therapy of Leukemia, FP7, number 306242 – the project goal is the application of the most modern approaches for genomics analysis for identification of novel diagnostics and prognostics biomarkers of leukemia and subsequent patient stratification and more effective application of therapeutical methodologies.
Projekt ALKATRAS (ALK activation as a target of translational science: break free from cancer, H2020, číslo 675712 ) – its main aim is to clarify yet unknown mechanisms of ALK-induced tumorigenesis and describe more specific role of oncogene ALK (anaplastic lymphoma kinase) in oncologic diseases like lymphomas, neuroblastomas and non-cell lung carcinoma (NSCLC).
University Hospital Brno
EF16_019/0000868 Molecular, cellular and clinical approach to healthy ageing. Grant provider: Ministry Of Health Of The Czech Republic, Main recipient St. Anne's University Hospital in Brno; Recipient: Dr. Gorazd B. Stokin, Period of research project: 2018 – 2023
NV15-30015A Analysis of clonal heterogeneity in chronic lymphocytic leukemia using next generation sequencing of B cell receptor. A national study. Grant provider: Ministry Of Health Of The Czech Republic; Main recipient: St. Anne's University Hospital in Brno, Recipient: Prof. MUDr. Michael Doubek, Ph.D., Period of research project: 2015 – 2018
Project supported by Agency of biomedical research (AZV, number 15-30015A ) entitled as „Analysis of clonal heterogeneity of chronic lymphocytic leukemia using next-generation sequencing of B-cell receptor gene. National study.“ has an ambitious aim to establish technology for high throughput sequencing of immunoglobulin genes and perform national screening of newly diagnosed CLL patients.
New-generation sequencing is used as a tool within the project entitled „Generation and development of genetic defects in leukemia“ (AZV, number 15-10035S) for identification of genetic disorders contributing to clonal evolution of leukemia and for study of B-cell receptor mediated signalling that both play important role in cellular response to external stimuli and thus contribute to clonal evolution.
Institute of Molecular and Translational Medicine - Olomouc
Information about current projects: https://imtm.cz/featured-research-projects.
VI20202022123 Epigenetic age of blood or sperm trace donor. Grant provider: Ministry of the Interior of the Czech Republic, Main recipient: Palacký University in Olomouc; Recipients: prof. Mgr. Jiří Drábek, Ph.D. a Mgr. Vilém Skyba; Period of research project: 2020-2022
MPO 67986/17/61600/3563 ENIGMA CZ - Czech National Genomic Map; Grant provider: Ministry of Industry and Trade of the Czech Republic, Main recipient: Institute of Applied Biotechnologies a.s., Period of research project: 2017-2022
ÚMTM addresses currently a number of international (EATRIS, FP7 INFLACARE, BBMRI etc.) and national grant projects (TACR, GACR, AZV etc.) focused on translational medicine, see more imtm.cz.